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Associate Scientific Director, Pharmacometrics

Posted on Apr 5, 2021 by Johnson & Johnson

Titusville, NJ 08560
Research
Immediate Start
Annual Salary
Full-Time


Job Description


Janssen Research & Development, L.L.C., a Johnson & Johnson company, is looking for an Associate Scientific Director to be located in Spring House, PA, Raritan, NJ, Titusville, NJ, or Malvern, PA!


At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow Research & Development, LLC is part of the Janssen Pharmaceutical Companies.


As the Associate Scientific Director, you will conduct advanced PK/PD modeling research with emphasis on disease progression modeling and implementation of mechanism-based approaches. You will support product development as Pharmacometrics Leader by defining the dose-concentration-pharmacological effect relationships of drugs using modeling and simulation methodologies from data acquired at various stages of drug research and development.


THE SUCCESSFUL CANDIDATE WILL ALSO:


Perform basic and clinical disease research, with a focus on Immunology, Oncology/Hematology, and/or Cardiovascular/Metabolic Disease compounds (small molecules, biologics, and other novel modalities such as gene-therapy).


Perform population PK and PK/PD analysis for key dose/regimen selections and regulatory submissions.


Use state-of-the-art computer modeling and simulation techniques to formulate various clinical trial design scenarios and outcome analyses.


Actively maintain relationships and collaborate with colleagues within or outside the Clinical Pharmacology and Pharmacometrics organization and J&J at large


Establish and Maintain external collaborations with Academic groups active in a variety of therapeutic areas worldwide.


Serve as senior technical expert for the Pharmacometrics organization in the application of advanced PK/PD and disease modeling principles, as well as in mechanism-based concepts and processes.


Qualifications


A minimum of a Master's degree in Pharmaceutical Sciences, Clinical Pharmacology, Chemical/Biomedical Engineering or related subject area with a minimum of 8 years of pharmaceutical development experience in various aspects of modeling and simulation is required


A PhD in Pharmaceutical Sciences, Clinical Pharmacology, Chemical/Biomedical Engineering or related subject area with a minimum of 6 years of pharmaceutical development experience in various aspects of modeling and simulation is preferred.


Hands-on experiences with population approach in describing PK/PD systems with various types of clinical pharmacology data is required.


Proven experience identifying research projects and successfully running them in collaboration with internal or external teams is required.


In-depth knowledge of preclinical or clinical pharmacokinetics, drug metabolism, PK/PD modeling principles and statistics is required.


Experience with NONMEM, R, Matlab, Monolix and/or other modeling and simulation software is required.


Thorough knowledge of planning, conducting, evaluating and reporting PK/PD studies in R&D is required


The ability to perform basic and clinical disease research, with a focus on Oncology/Hematology, Immunology and/or Cardiovascular and Metabolic Disease compounds is preferred.


Experiences with Quantitative Systems Pharmacology (QSP) is preferred but not required


Excellent communication and interpersonal skills is required


Experience with biologics drug development is preferred


Experience working with cross functional teams is helpful.


Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.




Reference: 1152694682

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