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Associate Director - Liver Disease Research and Drug Discovery

Posted on Apr 5, 2021 by Takeda Pharmaceuticals

Boston, MA 02297
Immediate Start
Annual Salary

Job Description
Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Lead in Liver Disease Research and Drug Discovery at our San Diego Research Site.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission. As an Associate Director on the Liver Disease Research team, you will be empowered to lead project teams in drug discovery.


The Associate Director, Liver Disease Drug Discovery working in the Gastroenterology Drug Discovery Unit will lead a team focused on the discovery and development of novel drug candidates for the treatment of chronic liver diseases

She/he will be a scientific leader with deep subject-matter expertise and will apply this expertise to leading cross functional efforts in the design and execution of in vivo and in vitro studies to generate key data for evaluating mechanism of action and/or drug candidate efficacy and pharmacodynamics. He/she will be responsible for bringing novel drug candidates with high potential for anti-fibrotic efficacy in humans into the early stage pipeline. She/he will need to be a highly collaborative and energetic scientist with superior communication skills, who can lead a lab-based team running multiple projects, act as senior scientific leader and/or lead early-stage Matrix project teams.


Develops and oversees novel scientific projects and will manage the work of others directly as well as in a matrixed structure
Oversees the design and execution of relevant target and drug candidate mechanism of action studies using contemporary methods and tools.
Lead cross-functional teams and provide technical leadership in area of expertise
Prepare technical reports, summaries and quantitative analyses in written and/or oral form
Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas
Manage a wide variety of tasks, techniques, and projects; integrate these responsibilities to produce quality result with a high level of efficiency
Supports or identifies BD opportunities to enhance project progression, or functional capability expansion, with clear and specific application to needs of the liver portfolio
Act as a scientific mentor
Communicate with colleagues effectively
Present data to other scientific staff or cross-functional project team; may present data/posters to external research or scientific community
Performs as a role model supporting Takeda culture and follow policies

PhD degree in a scientific discipline with 10+ years experience in drug discovery or target validation research with proven expertise in liver diseases
Expertise in the design and execution of in vivo and in vitro studies for the evaluation of liver-related biology and NASH/fibrosis pathology
Deep knowledge of animal models of liver disease, NASH and fibrosis and cell systems for evaluating interactions between hepatocyte, macrophage, stellate and/or endothelial cells
Expertise in one therapeutic modality (small molecules, antibodies & biologics, ASOs/siRNA) and familiarity with other modalities
Demonstrated ability to independently solve scientific problems using multiple technologies and approaches
Excellent oral and written communication skills

The position is based in San Diego, CA.
Requires approximately 15-20% or more travel, including international travel

Reference: 1152695154

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