Scientist - Inflammation Biomarker Discovery
Posted on Apr 5, 2021 by Amgen
Let's do this. Let's change the world. The Inflammation Research is seeking a highly motivated scientist to study disease mechanisms and develop preclinical biomarker plans to support our pipelines in asthma, COPD, and other inflammatory diseases. In this vital role you will focus on the discovery of biomarkers to support the progression of therapeutic candidates from discovery to early clinical development.
Develop deep disease area expertise for key indications
Investigate disease biology and heterogeneity using human genetics, single cell transcriptomics, proteomics, cellular assays and/or inflammatory disease models
Discover and prioritize disease stratification and target engagement biomarker candidates for multiple pipeline projects
Generate and transition key pharmacodynamic and patient stratification biomarker discovery data to support clinical biomarker assay development
Work together with the Clinical Biomarker Lead to support translational biomarker activities for therapeutic assets, including presenting at investigator meetings and advisor boards, and participating in investigator-sponsored studies
Publish and present at national/international conferences
The role is expected to work in a highly matrixed environment to drive scientific and technical innovation collaboratively with other members of the Inflammation group, as well as with other functions including the Clinical Biomarker & Diagnostics Team, Translational Medicine, Human Genetics and Computational Biology.
WHAT WE EXPECT OF YOU
We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a Scientist with these qualifications.
Doctorate degree plus 2 years of scientific experience
Master's degree plus 4 years of scientific experience
Bachelor's degree plus 6 years of scientific experience
Ph.D or MD, with postdoctoral trainings and research experience in the field of immunology, human genetics or molecular biology
Demonstrated track record of independent critical thinking and scientific achievement in research, exemplified by a strong publication record and/or significant contributions to a therapeutic development or biomarker discovery program
Technical expertise in one or more of the following areas: Multi-color flow cytometry, complex cell-based functional assays, genetic manipulation of cell lines and/or primary cells, cell signaling/biochemistry, in vivo mouse models of disease, and bioinformatics
Strong verbal and written communication skills. Ability to collaborate and troubleshoot to solve problems
Experience with implementing multiple technology platforms
Experience working in teams and consistently delivering results