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Senior Scientist Motility In Vivo Pharmacology

Posted on Apr 5, 2021 by Takeda Pharmaceuticals

San Diego, CA 92101
Research
Immediate Start
Annual Salary
Full-Time


Job Description
Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist GI Motility In Vivo Pharmacology at our recently dedicated San Diego Research Site.
At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Here, you will be a vital contributor to our inspiring, bold mission. As a Scientist on the GI team you will be empowered to serve on projects for discovery to development programs.
OBJECTIVES/PURPOSE
Apply advanced in vivo pharmacology technical skills and lead in vivo pharmacology activities in Gastrointestinal (GI) Motility Disorders in the GI Drug Discovery Unit to advance programs while meeting high standards of operational and pharmaceutical excellence
Oversee the development and implementation of effective in vivo screening paradigms for the evaluation of drug leads for modalities including small molecules, antibodies/peptides, and cell/gene therapy
Provide critical oversight and direction for the use of in vivo studies, including the development and application of new models
Communicate and collaborate across groups to ensure effective and efficient prosecution of programs
ACCOUNTABILITIES
Design and implement in vivo studies aimed at evaluating assets from early discovery through to support of clinical stage programs
Plan, design, and coordinate internal studies and studies in partnership with external CRO and academic partners
Collaborate with program leaders to ensure in vivo functional support and timely progress of drug discovery programs
Contribute hands on to study execution in particular as it relates to studies assessing cell therapy modalities that require advanced technical skillsets/surgical techniques
Ensure compliance with good laboratory practices and other regulatory guidelines
Prepare Research Reports for IND/NDA submission
Design experimental strategies to meet research goals in collaboration with discovery project teams
Present data to senior leadership, scientific collaborators and at relevant scientific conferences
DIMENSIONS AND ASPECTS
Technical/Functional (Line) Expertise
Expert in design, execution, and interpretation of in vivo pharmacology studies assessing potential drug candidates
Proficiency in small animal surgery and complex surgical models in rodents
Knowledge and experience of cell therapy and the assessment of cell therapies in animal studies
Demonstrated knowledge and experience in conducting studies assessing function of the GI tract in rodents
Expertise in GI physiology and pharmacology
Practical knowledge and experience in transgenic animal generation and breeding
Leadership
Experience supervising laboratory staff
Excellent communication and multitasking skills and ability to work effectively in a team setting
Ability to convey ideas and vision to influence at all levels of the organization
Decision-making and Autonomy
Independently designs experiments, manages workload for self and team, assigns duties to laboratory personnel, analyses and interprets data
Ability to identify and solve complex problems
Demonstrates effective decision-making to guide and prioritize activities to support drug discovery programs
Interaction
Engages with and may lead partnerships with external collaborators
Works cross-functionally ensure alignment and support of projects and initiatives
Innovation
Ability to identify novel approaches and develop new methodologies to impact the business
Demonstrated independent thought and scientific creativity
EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
PhD degree in a Cell and Molecular Biology, Neuroscience or related field with 5+ years
experience, or
MS with 10+ years experience, or
BS with 12+ years experience




Reference: 1152695502

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