Senior Scientist, Cancer Drug Discovery
Posted on Apr 5, 2021 by Bristol-Myers Squibb
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The new Bristol-Myers Squibb research site in Cambridge's Kendall Square will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation and business opportunities.
The Mechanisms of Cancer Resistance Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.
Sr. Scientist, Cancer Drug Discovery
The Sr. Scientist will join the Oncology Resistance Biology research team at Bristol-Myers Squibb (BMS) in Cambridge, MA. This team is composed of cancer biologists, cancer geneticists, and immune-oncologists who collaborate to develop therapies to address mechanisms of resistance to BMS immune oncology agents.
The qualified candidate is a highly motivated, interactive, and creative individual who possesses substantial experience in studying tumor biology and genetics, especially with respect to how these features impact immune responses to the tumor. The candidate will be expected to contribute to the team's project portfolio by developing new project hypotheses (gleaned from literature reports, evaluation of public and proprietary tumor profiling datasets, preclinical mechanistic models and screens, etc.), validate hypotheses in preclinical models, and develop assays to support early preclinical drug development. The opportunity to gain experience in preclinical drug development is available as successful hypotheses progress into later stages of preclinical development. The highly matrixed organization also provides the opportunity for the successful candidate to broaden their scientific expertise into both cancer intrinsic and extrinsic drivers of resistance.
The successful candidate will demonstrate clear and professional verbal and written communication, capable of presenting scientific results to multidisciplinary teams, senior management and at external scientific meetings. The candidate will contribute to the development of external partnerships/collaborations to advance internal programs and the understanding of the interplay between tumor genetics/biology and anti-tumor immune responses as well as publish to advance our science and support our scientific reputation. As a highly matrixed working group, the individual should demonstrate the ability to contribute to various projects outside of his/her own, as appropriate, and collaborate with stakeholders from all relevant and necessary functions within BMS as well as external collaborators. S/he will keep up-to-date in the literature related to his/her field, act as an expert resource in his/her scientific field and in related disciplines.
A Ph.D. degree with post-doctoral/academic/industrial experience in cancer biology and genetics or immune-oncology, and up to 3 years of industry experience
A proven track record in the field of cancer biology and genetics or immune-oncology, as evidenced by publication record
Excellent in vitro biology skills, experimental design and execution, as well as expertise to independently apply bioinformatics and data mining through multi-variate analysis
Ability to effectively interact with core bioinformatics colleagues, as well as to use desktop tools/interfaces (eg, Oncoland, Wuxi) and public databases (CBIO, Achilles, etc.)
Excellent interpersonal skills with the ability to interact and influence effectively with people, internally and externally, is required.
The ability to manage 1-2 scientists is expected, including providing growth and development opportunities for reports