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Principal Scientist, Bioconjugation and Oligonucleotide Chemistry

Posted on Apr 5, 2021 by Takeda Pharmaceuticals

San Diego, CA 92101
Immediate Start
Annual Salary

Job Description
Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as an Oligonucleotide Lead in our San Diego, CA office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.


Independently designs and implements extensive scientific research projects relating to the development of antisense oligonucleotide or siRNA therapeutics. Contributes to multiple projects, acting as senior scientific consultant, may be a project team leader or providing key technical knowledge to a project team.

Plays a leading role in the identification, development, validation and implementation of both current and next-generation delivery technologies to enable proprietary ASO and siRNA therapeutic development including purchase and installation of hardware and software supporting synthesis, purification, and characterization of oligonucleotides

Executes or directs bioconjugation of targeting ligands to oligonucleotides in the lab and/or through effective management of external CRO teams
Demonstrates working knowledge of techniques aimed at producing novel conjugates of oligonucleotides, peptides, small molecules, and proteins
Build and lead a small internal team of chemists and manage external CRO workstreams as needed.


Technical/Functional (Line) Expertise

Proven track record of scientific contributions in the bioconjugation and oligonucleotide research/development as evidenced by quality and quantity of publications/presentations/inventions and/or products and clinical candidates
Demonstrates a deep understanding of the chemistry of nucleosides, nucleotides, and oligonucleotides as applied to both antisense oligo and siRNA technology within a multi-disciplinary drug discovery environment.
Maintains a current appreciation of the scientific literature and understanding of the state of the art in ASO and siRNA chemistry, purification, and screening strategies
Demonstrates inter-disciplinary knowledge of drug discovery (in vitro/in vivo pharmacology, ADME, PK/PD, translational research & toxicology).
Demonstrates strong analytical; and bioanalytical skills to characterize oligonucleotides and their conjugates using a variety of techniques including but not limited to LC-UV-HRMS, SEC/SAX/IPRP, Gel based methods, fluorophore labeling.

Recognized as a major contributor and/or leader of multi-disciplinary projects, with significant accountability for progress on projects important to achieving site goals.
Prepares and organizes data for presentation. Communicates strategy and results in written and oral reports to various levels of management. Communicates research efforts to collaborators, corporate partners, or at scientific meetings.
Strategic direction of bioconjugation and oligonucleotide chemistry capability development at Takeda. Identifies, proposes and develops new solutions to discovery strategy.
Strong and effective manager of both junior and senior scientists, demonstrating exemplary behaviors and able to support and enhance career development of all line reports.
Scientific driver for research strategy that impacts group internally and outside area of function.
Highly motivated and flexible with ability to work in fast-paced environment. Ability to provide novel creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.
Decision-making and Autonomy

Scientific driver for research strategy that impacts group internally and outside area of function


Provides expert input in evaluation of external/partnership opportunities, including participating in diligence exercises. Initiates and leads external interactions and collaborations.
Positive can-do attitude with excellent communication and collaboration skills and ability to work with cross-functional scientists. Ability to clearly and concisely conveys ideas and opinions.

Leads effort to identify emerging trends in bioconjugation, targeted delivery of oligonucleotide therapeutics and maintains awareness of competitive landscape
Develops and contributes to company's intellectual property domain by way of patents and publications.

Ph.D. in Organic Chemistry (or a related field) with thesis, publication(s), postdoctoral experience, and a minimum of 8 years relevant scientific and technical experience including industry experience, or
MS with 12+ years experience, or
BS with 14+ years experience

Reference: 1152695736

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