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Associate Director/Director, Investigative Toxicology

Posted on Apr 5, 2021 by Takeda Pharmaceuticals

Cambridge, MA 02138
Immediate Start
Annual Salary

Job Description
Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as an Associate Director/Director, Investigative Toxicology in our Cambridge, Massachusetts office.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As a Leader Investigative Toxicology, you will be empowered to provide leadership and global functional expertise for projects in the Takeda portfolio.


Lead Investigative Toxicology | Lead a team of investigative toxicologists detecting and de-risking toxicities in a fast-moving portfolio focused on new modalities.
Help us make safer drugs | The next generation of life changing medicines include gene therapies, oligonucleotides, cell therapies and other new modalities - all honed to treat previously untreatable diseases. Help us shape this next generation of life-saving medicines by improving the design of next-generation therapeutics based on proactive detection & de-risking of dose limiting toxicities.
Deliver decision-making data | Lead a team of talented scientists delivering state-of-the-art in vitro assays to detect & de-risk toxicity for medicines in discovery & development. Help shape the evolution of new therapies to deliver safer & more effective medicines for patients with rare diseases.

Lead toxicological investigations to detect & de-risk toxicities in drug discovery and development using in vitro and in vivo data.
Use cutting edge molecular and cellular technologies to help make the next generation of gene and cell therapies. From single cell RNAseq to organ on a chip technologies - we are looking for scientists with an incredibly deep toolset to solve problems facing a vast field of new modalities.
Probe molecular and cellular mechanisms of toxicity to determine drivers of liver, cardiovascular and other toxicities and guide drug projects to make safer medicines using your experience, in-house, and literature data.
Drive the development of safer gene and cell therapies using in vitro and in vivo data from a matrixed project team.

PhD in biology, pharmacology, toxicology or a related discipline with at least 8 years of pharmaceutical toxicology experience.
5y of Industry experience.
5y of management experience.
Experience with conventional and advanced cell culture approaches with cell lines, primary cells, and iPSC cells.
Experience working with new modalities - including gene, cell, nanoparticle and/or microbial therapeutics is highly desirable.
Experience working in a matrixed team environment at a pharmaceutical company and/or CRO is essential.
Broad scientific knowledge including pharmacology, toxicology, pathology, physiology and biochemistry.
Expertise designing & delivering fit for purpose assays for understanding the mechanism of toxicity of agents including drugs, for biomarker development and application, and for de-risking drug candidates.
Experience with organ systems in addition to liver such as cardiovascular, GI, and immune systems is highly desired
Strong interpersonal and organizational skills, especially as a manager, a plus.
Excellent oral and written communication skills

Reference: 1152694492

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