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Senior Scientist, Bioprocess R&D Upstream Development

Posted on Apr 6, 2021 by Pfizer

Chesterfield, MO 63005
Immediate Start
Annual Salary


As a member of the Bioprocessing R&D Upstream Development department, the Senior Scientist will help drive the advancement of microbial/mammalian cell culture processes for recombinant proteins and biologics for early- and late-phase clinical trials. As a Senior Scientist you will design and execute microbial/mammalian cell culture experiments and drive innovative collaborations and technology development projects to deliver robust, scalable, and highly productive upstream processes. You will work with pilot scale, commercial, and clinical production facilities to deliver accurate technology transfer for successful large-scale production. The successful candidate will be part of a team of scientists from diverse functional areas to enable the delivery of life-changing medicines to patients.

We are seeking a highly motivated and results-oriented self-starter who demonstrates personal accountability for outcomes and thrives on increasing levels of responsibility.

We are committed to breakthroughs that will changes patient lives and welcome colleagues that share our passion.


Responsible for successful development, characterization and execution of state-of-the-art manufacturing processes for mammalian and microbial cultures.
Applying scientific and technical experience to establish strategies, drive safe and high-quality lab technical work, deliver well-controlled and characterized manufacturing processes.
Develops creative and pragmatic technical and operational problem-solving options.
Design and conduct bioreactor and shake-flask experiments to develop and test new hypotheses to enhance the fundamental understanding and performance of cell culture medium and processes.
Ensures effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks and internal Technical Reports; presents data/strategy to scientists and management in appropriate internal and external venues (technical meetings, Project Team meetings, conferences) and publishes in peer-reviewed journals, as appropriate.
Contributes to safe, efficient, effective and harmonious lab environment through personal responsibility/accountability.
Ensures appropriate cleanliness and status/operability of shared or assigned lab space or equipment; strong lab citizen and collaborative team player; approaches the job with energy and commitment; demonstrates initiative.
Demonstrates leadership and capability to mentor junior colleagues, and fosters a team environment.
Has the ability to troubleshoot scientific and technical challenges, and contribute to their resolution.

PhD degree in Chemical/Biochemical Engineering, Biotechnology, Cell Biology, Microbiology or a relevant field with 0-3 years in biotechnology/biopharma industry in the development and characterization of mammalian cell culture processes.
MS in Chemical/Biochemical Engineering, Biotechnology, Cell Biology, Microbiology or a relevant field with 7+ years of experience
BS in Chemical/Biochemical Engineering, Biotechnology, Cell Biology, Microbiology or a relevant field with 9+ years of experience
Advanced experience in upstream process development.
Expertise in operating lab scale mammalian or microbial culture bioreactor systems and computerized process control equipment.
Demonstrated success leading and executing independent research or technology development projects for the production of biologics.
Self-motivated, organized, and capable of working independently and in a collaborative environment.
Strong oral and written communication skills, attention to detail and demonstrated ability to execute detailed experimental plans, record procedures, analyze data, and present results.
Ability to work in a fast paced team environment with changing priorities.
Has a good understanding of microbial and mammalian cellular metabolism.

Experience in statistical experimental design and analysis of biological processes.
Proficiency in using software tools for design of experiments, statistical analysis and data visualization - including Design-Expert, JMP, and Spotfire.
Experience in the development of bioreactor scale-down models and process scale-up.
Experience tuning bioreactor control systems.
Proficiency in a programming language.


Position requires occasional light lifting and periods of standing, sitting or walking. Some regular air travel required.

Occasional weekend work required.
Occasional travel domestically to support technology development and/or clinical manufacturing activities as well as technology transfer to commercial manufacturing

Reference: 1152635646

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