Principal Scientist/Associate Director - Immunology & Cell Biology
Posted on Apr 6, 2021 by AstraZeneca
At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe!
We are seeking a highly skilled and motivated Ph.D. Scientist with strong immunology and cell biology background to join our Group within Integrated Bioanalysis in Gaithersburg, MD. The position will take a lead role in developing and implementing bioanalytical strategies for advancing our drug pipeline and working as the group representative in multidiscipline drug development teams.
The position is in our Integrated Bioanalysis Department which is part of the Clinical Pharmacology and Quantitative Pharmacology Group, and is responsible for providing high quality, decision-driving data using a variety of platform and novel technologies. Our team primarily focusses on early R&D pre-GLP bioanalyses along with exploratory biomarkers assessments applicable to all therapeutic areas. We have a diverse array of scientists working across many technologies to ensure delivery of critical assays, and data analysis that drive go/no go decisions and ensure the right combination of medicines get to the right patient, in the right dose, and at the right time.
What youll do
Develop and implement bioanalytical strategies to support drug programs (eg, Oncology, Respiratory and Immunology) from lead candidate selection through clinical trials.
Build a platform of in vitro immunogenicity assessment for high risk biologics and new modalities (eg, CAR-T, T cell engaging antibody circuits) to enable lead selection and assess the potential risk of cytokine release syndrome.
Represent the department on multidiscipline drug development teams, thus ability to support other technologies, especially ligand binding and cell-based functional assays will be a benefit.
Supervise associate(s)/scientist(s) and take a lead role in pushing the boundaries in determining lead drug candidates and facilitating global clinical trials.
Essential for the role:
Ph.D. in immunology, cell Biology, or other related scientific discipline and post-doctoral experience in related areas.
Strong background in immunology, cancer biology and experience with diverse immunologic assays.
7-10 years of experience in academia or industry coming from projects that developed advanced immune cell function assay development (eg, human T cell based) and data interpretation skills.
A high level of independence and with an ability to develop hypotheses and execute analysis plans for pharmacokinetics, pharmacodynamics and proteomics biomarker data.
Attention to details, good communication and collaboration skills. Outstanding record-keeping skills are critical for success.
An ability to think and act creatively- independently, and within collaborations.
Desirable for the role
Experience with molecular techniques and applications for genome sequencing, qPCR, qRT-PCR.
Experience with advanced data analysis tools for analyzing and visualizing biomarker data (highly valued).
Experience with broader Immunoassays eg ELISA, multiplex assays, Elispots etc.
Knowledge of GxP regulations.