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Computational Chemist

Posted on Apr 6, 2021 by AstraZeneca

Waltham, MA 02451
Research
Immediate Start
Annual Salary
Full-Time


Site Description
Welcome to Cambridge, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca's priorities, it's important to us that you bring your full self to work every day. To help you maintain your best self, here's a sneak peek into some of the things this site provides for you.


Where life meets Science Chesterford Research Park offers advanced laboratory and office space set within 250 acres of idyllic parkland near Cambridge - modern, dynamic, flexible facilities perfectly appointed for biotechnology, pharmaceutical and R&D companies. You will have access to a stylish, fully air conditioned health and fitness centre, an onsite restaurant, Lunch & Learn development activities, all within a bright and spacious environment while utilising the most advanced technology.


Business area
At AstraZeneca, we consider ourselves to be bold innovators, our pipeline is one of the broadest and deepest in the industry, whilst our cutting-edge work and ground-breaking approaches keep pushing us forward, harnessing digital technology, data and AI as we fast-forward progress and transform Healthcare.


We have achieved a lot in a short space of time by focusing on our pipeline and evaluating novelty and clinical development movement. In 2019 and 2020 we were ranked at the top of the invention scale with best pipeline by IDEA Pharma'. But the next chapter of our pipeline is more exciting than ever We have an ambitious goal to deliver 6 new molecular entities by 2025. It is up to each of us to keep pushing forward and pioneer new approaches. From bold innovations and integrated healthcare systems to harnessing data and technology. We have multiple indications and many high-quality molecules at all stages of development - but we see even more potential.


What you'll do
As a computational chemist with a passion for drug discovery and significant experience of working in drug discovery project teams within a biotech or pharmaceutical setting, you will join an established group of computational chemists working on oncology drug discovery projects across a range of modalities and will have access to state-of-the-art computational methods and lead generation capabilities.


You will be a leading member of the medicinal chemistry design team, responsible for:


Setting and delivering on computational and medicinal chemistry strategies to impact project success at all stages from drug target identification through to clinical candidate nomination.
Working with a high degree of independence, you will carry out structure- and ligand-based design and data analysis, extracting insight from large proprietary structural biology and SAR data sets; your contributions to molecular design will be expected to result in inventorship on patent applications.
You will work closely with scientists from other disciplines including structural biology, biophysics, ADME/DMPK and safety sciences as part of the wider drug discovery project team, and will present your work regularly to peers and senior stakeholders. Depending on experience and interest, you might also function as the lead chemist for a drug discovery project.
At AstraZeneca we value scientific innovation. Maintaining an awareness of the current state-of-the art, you will identify promising new computational methodologies or technologies that could benefit drug discovery, and will develop and implement these through internal or external collaborations across AstraZeneca. You will be expected to publish your work regularly in high quality scientific journals and at national and international conferences.
You'll have the opportunity to supervise PhD students and postdocs through academic collaborations, as well as to mentor colleagues.
Essential for the role
Profile


Ph.D. degree in computational chemistry, or B.Sc./M.Sc with equivalent experience
A minimum of 3 years' experience working as a computational chemist on predominantly small molecule drug discovery projects in a Pharmaceutical or Biotech setting.
Broad experience in structure and ligand-based design, data analysis and property prediction
A passion for drug discovery and an excellent understanding of medicinal chemistry concepts
Innovative problem-solver, with a track record of impacting drug project delivery
Strong oral and written communication skills, team-working and time-management skills




Reference: 1152692892

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