Research Scientist - Immunogenicity and Translational Bioassay
Posted on Apr 6, 2021 by Takeda Pharmaceuticals
Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Research Scientist I - Immunogenicity and Translational Bioassay in our Cambridge office. At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Here, you will be a vital contributor to our inspiring, bold mission.
We are seeking a highly motivated and well accomplished scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) Department of Takeda Pharmaceuticals in Cambridge, MA. This scientist will support the advancement of drug discovery programs from concept to clinical translation in partnership with Drug Discovery Units (DDUs), Therapeutic Area Units (TAUs) and Research and Development functions across Takeda. The support includes engaging with colleagues across Neuroscience, GI, Oncology and Rare Disease R&D to ensure rapid and thorough translation from pre-clinical studies to clinical studies. Experiences in immunology, immune-oncology, cell therapy or gene therapy is preferred.
Develop and implement quantitative/qualitative experimental studies to support translational research and immunogenicity risk prediction for immuno-oncology and rare disease discovery and development programs.
Build new technical capabilities and support new modality programs in different therapeutic areas
Develop strategies and technical assays to support both discovery and development projects, and ensure effective achievement of DMPK objectives.
Represent DMPK in discovery and development project teams as subject matter expert. Coordinate all DMPK related assays, and initiate and engage in multifunctional collaborations to facilitate the advancement of drug candidates and build thorough knowledge of biologics properties
Play a visible role in global DMPK to share learning and enhance consistency in best practices across sites and disease areas about immunogenicity prediction of different modalities.
Keep up to date with emerging literature and science in the biologics development in Immuno-Oncology
Ph.D. degree (preferred) in a scientific discipline (Immunology, Biology, Pharmacology, or Pharmaceutical Sciences) or MS with 6+ years experience, or BS with 8+ years experience
Demonstrates theoretical knowledge of discipline and effective project management skills.
Hands-on laboratory experiences with basic immunology assays (flow cytometry, ligand binding assay such as ELISA/ELISPOT, cellular biomarker and translational assays, and primary cell isolation and culture) are preferred
Knowledge in basic cell biology, immunology, pharmacology or familiar with new discovery and findings in Immuno-oncology space.
Excellent written and oral communication skills to effectively communicate complex research findings and recommendations, and seek to excel in a multi-disciplinary team environment.
Ability for critical thinking and strong analytical skills to evaluate complex information for the identification of key scientific findings related to projects.
Ability to prioritize and manage multiple projects and activities while meeting tight deadlines
Maintains excellent working relationships with colleagues and collaborators