Posted on Apr 6, 2021 by Bristol-Myers Squibb
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Leads Discovery & Optimization (LDO) is a dynamic organization that supports the entire continuum of drug discovery (from lead identification to clinical candidate delivery) at Bristol Myers Squibb. The organization leverages state of the art technologies, complemented by deep subject matter expertise and broad scientific knowledge, to deliver innovative and comprehensive preclinical in vitro datasets to support our drug discovery pipeline in disease areas such as cell therapy, oncology, immunology, fibrosis and cardiovascular diseases.
As a Sr. Scientist within the LDO, this individual will be responsible for the design, validation, execution, and interpretation of cell-based and biochemical assays for high throughput screening through lead optimization, in support of the broad BMS portfolio. This individual will have the opportunity to work on cross-functional drug discovery teams, closely interacting with colleagues from different functions including chemistry, biology, DMPK and pharmacology. The individual will collaborate within LDO and across project teams to help shape the in vitro screening strategy, identify appropriate assay platforms, and develop high throughput assays using cutting-edge automation platforms. The ideal candidate will have a strong working knowledge of fundamental principles of in vitro pharmacology and cell culture, including receptor-ligand interaction and intracellular signaling transduction pathways. In addition, hands-on experience with both protein (HTRF, BRET, luminescence, ALPHA technology, ELISA, western, etc.) and nucleic acid-based (RT-qPCR) cellular assay formats is strongly desired. This is a laboratory-based position.
The Sr. Scientist will be expected to prepare and deliver effective presentations to project stakeholders. The ideal candidate will balance technical skills with critical-thinking and have demonstrated a track record of rapidly driving high-quality, high-impact projects to completion. The successful candidate will have a can-do attitude and a drive to proactively facilitate the continuous improvement of processes and culture.
Provide scientific and technical leadership within both the LDO and disease project teams
Design, optimize, and validate assays for small molecule plate-based assays and high throughput screens
Utilize appropriate software and analytical tools to interpret and apply quality control measures to screening data
Effectively compile and present data to project teams in both written and oral formats
PhD with 0-2 years of relevant experience, or M.S. with 5 years or more of experience in cell biology or related scientific discipline, with preference for industry experience
In depth knowledge of general bioassay approaches such as fluorescence, HTRF, and luminescence
Hands on experience with automated liquid handlers and microtiter plate readers
Practical experience in cell culture, cell-based assay development and execution, with a strong background in de novo assay design, quality control, and high-throughput processes is a significant plus
Strong written and verbal communication skills and demonstrated strength in a Matrix organization
Track record of successful multitasking and rapid execution
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