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Principal Scientist, Drug Discovery

Posted on Apr 6, 2021 by Bristol-Myers Squibb

Cambridge, MA 02138
Research
Immediate Start
Annual Salary
Full-Time


Job Description
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.


Principal Scientist (Drug Discovery)


At Bristol Myers Squibb (BMS), we are inspired by a single vision - transforming patients lives through science. In oncology, hematology, immunology, and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.


The new Bristol-Myers Squibb research site in Cambridges Kendall Square will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. The Mechanisms of Cancer Resistance (MoCR) Thematic Research Center (TRC) at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus.


We seek a highly motivated, passionate, and collaborative scientist with demonstrated experience in oncology drug discovery and preclinical development to join BMS in Cambridge, MA. We are a fully integrated drug discovery and early clinical development organization which exploits state-of-the-art technologies to build a one-of-its-kind pipeline with the highest potential to meaningfully improve lives of cancer patients with the utmost clinical need. The ideal candidate will have a deep understanding of tumor intrinsic biology, preclinical pharmacology, and mechanisms of response and resistance to cancer targeted therapies. The qualified candidate will have the opportunity to lead preclinical drug discovery programs to the clinic in close collaboration with global cross-functional teams, including chemistry, in-vivo pharmacology, toxicology, DMPK and translational biology. S/he will manage a preclinical biology lab and supervise a team of associates to support their project responsibilities and contribute to team held objectives, including but not limited to investigation of drug mechanisms of action, pharmacodynamics readouts, and exploring therapeutic hypotheses. Excellent oral and written communication skills with the ability to thrive in a Matrix environment are required. The successful candidate will have the presentation skills to influence and inform scientific decisions at senior management, cross-functional or external meetings. The candidate will have opportunities to mentor postdoctoral scientists, develop and foster external partnerships or academic collaborations to advance internal programs, as appropriate. BMS is committed to people development and we foster a learning environment to build scientific and leadership skills. In addition to leading scientific projects, candidate will also be able to participate in and lead site initiatives, and influence broader portfolio, strategic and business development decisions.


Qualifications


Required


- A Ph.D. degree with a minimum of 5+ years of relevant industry experience in cancer biology and oncology drug discovery


- In-depth knowledge of cancer cell biology, cancer cell signaling, assay development and pre-clinical pharmacology


- Demonstrated ability to advance preclinical drug development from target to clinical candidate


- Thrives in fast-paced, dynamic work environment, bringing a pro-active mentality to the role


- Demonstrated ability to effectively influence stakeholders in a dynamic, matrixed organization


- Excellent interpersonal, oral and written communication skills


Preferred


- Experience in small molecule oncology drug discovery is highly desired


- Ability to innovate in novel preclinical in vitro, in vivo and ex vivo oncology model development that enables bridging from pre-clinical tumor biology to patient setting is desired


- Management/supervisory experience




Reference: 1152693085

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