Scientist II, Analytical Method Development & Characterization (Biologics)
Posted on Apr 6, 2021 by Nektar Therapeutics
Nektar has an exciting opportunity for a Scientist II, Analytical Method Development & Characterization (Biologics) to join their team.
Scientist II, Biologics Analytical Development, part of Nektar Biologics CMC organization is responsible for product characterization, analytical method development/qualification of proteins and protein-conjugates for Nektar Biologic products in pre-clinical and clinical development stages. Conducts and collaborates with others on analytical issues relevant to long-term objectives and concerns. Develops testing methodologies to support process development of drug substance and drug product. This position contributes to and supports the company's research development and manufacturing to create high value therapeutics to address unmet medical needs.
The successful candidate will be responsible for:
Characterize protein polymer conjugates to elucidate conjugate sites and distribution
Develop and validate analytical methods to support late stage drug development activities
Assist process development scientists to characterize and monitor in-process purification
Transfer analytical methods to internal QC group or CRO for drug substance and drug product release testing
Summarize experimental data and write technical reports
Use professional concepts and companys policies and procedures to solve a wide range of difficult problems in imaginative and practical ways
May determine methods and procedures on new assignments and recommend new methods and procedures
May provide guidance to other lower level personnel
Communicate cross-functionally with groups such as research, process development, formulation development, manufacturing, QC group and CRO/CMO to ensure appropriate project support
Maintain a current knowledge of latest technological/scientific trends
A PhD in a scientific discipline is required. Equivalent experience may be accepted. A minimum of 4 years work experience in a research and/or development environment is required. Post-doctoral work may serve as experience. Exceptional non-PhDs with demonstrated capabilities and/or significant experience may also be considered.
Must have extensive experience in HPLC Analysis of Proteins. Must have in-depth knowledge and hands-on experience in analytical method development and characterization for biologics
Must be able to demonstrate potential for technical proficiency, scientific creativity, collaboration with others and independent thought
Must be able to clearly communicate scientific information both written and oral.
Experience in HPLC separation methods such as ion exchange, reversed phase, and size exclusion chromatography, and capillary electrophoresis for proteins is highly desirable
Works on problems of moderate scope in which analysis of situation or data requires a review of identifiable factors
Experience in technology transfer to internal QC lab or CRO in support of drug substance/drug product release testing is highly desirable
Good computer skills are required. Working knowledge of MS word, Excel, Power point is a plus
Must be willing to work as part of a team