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Principal Scientist, Team Lead for Small Molecule Separation

Posted on Apr 6, 2021 by Bristol-Myers Squibb

Cambridge, MA 02138
Research
Immediate Start
Annual Salary
Full-Time


Job Description
At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.


Team Lead for Small Molecule Separation, Cambridge, MA


This individual will be responsible for providing separation science support for the drug discovery/medicinal chemistry team at BMS in Cambridge MA. He or she will lead a team of scientists, including external service providers, to deliver non-GLP separation science support for the site. A particular focus will be managing a high throughput small molecule purification service, using both preparative liquid chromatography (HPLC) and preparative supercritical fluid chromatography (SFC), for achiral and chiral separations. In addition to method development and purification, the candidate will provide limited onsite support for separation and physical property measurement, and will coordinate with team members at other sites to deliver capabilities not available locally. He or she will also ensure operational support of a fleet of analytical LCMS instruments used by medicinal chemists for routine reaction checking and compound QC. He/she will work with other team members to ensure that the infrastructure is fully operational, to track usage and output metrics, to interact with medicinal chemists, and to troubleshoot problems as they arise. He/she will also work with the external service provider to ensure that scheduling and training are matched to requirements to ensure smooth and efficient operation of the lab.


In addition to the operational role described above, the individual will be responsible for working with management to develop, implement, and update the strategic plan for separation science at the site, and for identifying and completing continuous improvement projects that may include chromatography method development, infrastructure improvements, IT and process improvements, quality improvements, etc. The site will be moving into a newly constructed building in 2023; the candidate will be responsible for participating in lab design and ultimately implementing move to the new building.


The candidate will have a Ph.D. degree in Organic or Analytical Chemistry and at least 3-7 years of relevant industrial experience or a Master's degree and at least 10-12 years of relevant industrial experience. He or she will have experience in analysis and purification of small molecules and/or peptides by reverse phase HPLC and SFC, and in mass spectrometry. Experience in a high throughput environment managing large numbers of samples and associated data and/or experience in organic and medicinal chemistry is strongly desired. The candidate will have demonstrated problem-solving skills, including troubleshooting processes, instruments, and data management issues. Experience in computer programming (one or more common or instrument-specific languages), laboratory automation, and/or process optimization are highly desired.


The successful candidate must be able to work independently, must have strong written and oral communication skills, and must have a proven record of accomplishment of successful project management and completion in a highly matrixed environment; supervisory experience in such an environment is desirable.


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.




Reference: 1152694372

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