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Scientist, X-ray Crystallography

Posted on Apr 6, 2021 by Johnson & Johnson

San Diego, CA 92101
Retail Trade
Immediate Start
Annual Salary
Full-Time


Job Description


Janssen Research & Development, L.L.C., a division of Johnson & Johnsons Family of Companies is recruiting for a Scientist, X-ray Crystallography, located in La Jolla, CA!


At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.


The Discovery Technologies and Molecular Pharmacology group is a dynamic, diverse and critical part of the Discovery Sciences organization in Janssen R&D. We are committed to the discovery and characterization of high-quality chemical leads needed for the generation of small molecule clinical compounds in all five Janssen Therapeutic Areas. This mission requires deep scientific expertise across broad subject areas including chemistry, cellular and molecular pharmacology, enzymology, screening, protein science, and structural biology coupled with an ability to work collaboratively with internal and external partners. Building on a strong Legacy of success, we are currently seeking an outstanding and motivated individual to join our team as Scientist, X-ray Crystallography.


As the Scientist you will:


Be an active member of drug discovery teams, working closely with computational and medicinal chemists on structure-based drug design approaches for small molecule agent optimization.


Be responsible for crystallization of protein-small molecule complexes, determination of high-resolution structures by X-ray crystallography and communicating these results to the project team.


Work closely with protein scientists, biophysicists, protein NMR and cryo-EM scientists as part of an integrated structural biology effort.


Contribute to multidisciplinary Fragment-Based Lead Discovery (FBLD) efforts.


Contribute to enhance the structural biology scientific expertise of the group by publishing high-impact research papers, and presenting at scientific conferences, internalizing impactful technologies and platforms, and establishing academic collaborations.


Mentor lab scientists and contribute to the strategic planning of the Structural Biology group.


Qualifications


BS degree with at least 12 years of experience, OR MS degree with at least 9 years of experience, OR a Ph.D. or equivalent and postdoctoral experience in structural biology (X-ray crystallography, biophysics, protein engineering) or related field is required


Expertise with crystallography software packages (Phenix/CCP4/PyMol/Moe) in a mixed Linux/Windows computational environment is required


Scientific expertise in structural biology, with strong experience in both protein crystallization and structure determination is required


Strong record of external publications and presentations is required


Outstanding written and oral communication skills are required


Experience in Structure-Guided Drug Design utilizing X-ray crystallography is preferred


Research experience in cryo-electron microscopy (Cryo-EM), Micro-electron diffraction (Micro-ED), protein NMR or orthogonal structural biology technologies is preferred


Research experience with other biophysical techniques such as MST, ITC, NMR, DSF, SPR is preferred


Broad knowledge of biophysics, biochemistry, molecular pharmacology, and protein sciences is preferred.


Experience in scientific programming (Unix shells, Python) is preferred


Expertise in one or more of the following therapeutic areas: Oncology, Inflammation, Neuroscience, Cardiovascular, and Infectious Diseases is preferred


Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.




Reference: 1152695798

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