Principal Scientist, Pharmacology
Posted on Apr 13, 2021 by Pfizer
We seek an accomplished Principal Scientist level oncologist to join the Pharmacology group within Pfizer Boulder Research (PBR), Boulder, Colorado. The successful candidate will join a dynamic team of scientists in the Pharmacology and Toxicology Group, playing a lead role in using models of cancer to evaluate new drug candidates, mechanisms, and targets.
The Principal Scientist will participate in exploratory in vivo biology, pre-clinical drug discovery/development programs, and translational studies with a focus on both immuno-oncology and tumor intrinsic biology. The candidate will contribute to the identification and characterization of new targets/therapeutic modalities and to the development of small molecule drugs in pipeline programs in close collaboration with partner lines. The ideal applicant will develop cutting edge in vivo mouse and human cancer models. The individual will provide technical and scientific expertise in in vivo pharmacology across PBR to enable target identification, validation, and prioritization and efficient drug discovery. Ideal applicants will be collaborative and team-oriented, possess excellent communication, leadership, and organizational skills, and have a commitment to excellence.
Work within multi-functional teams to support small molecule drug discovery.
Serve as the in vivo pharmacology lead on several drug discovery programs.
Design and conduct in vivo pharmacology studies to evaluate PK, PK/PD, efficacy, and therapeutic index.
Develop and characterize new in vivo mouse models, including syngeneic tumor and human cell line/PDX models, to support exploration of novel therapies and to study biological mechanisms.
Interpret, present, and document experiments within an electronic lab notebook, as well as prepare reports for regulatory documents such as IND filings.
Provide written and verbal presentation of results within a multidisciplinary team environment.
PhD in immuno-oncology, oncology, in vivo pharmacology, or a related discipline, with > 8 years of post-doctoral experience (including at least 3 years of experience in drug discovery in the pharmaceutical industry).
Expertise in designing and performing a variety of efficacy and pharmacodynamic studies; experience in contributing to safety pharmacology and toxicology studies is a plus.
In vivo pharmacology skills with animal models, including animal handling and restraint, compound dosing, tumor implantation, blood and tissue sampling, small animal surgical techniques, necropsy procedures, and physiological monitoring.
Ex vivo and in vitro skills, including flow cytometry, Western blotting, and ELISA.
Current knowledge of immuno-oncology and cancer research, with an ability to follow novel scientific/technological developments for implementation in the lab.
Proven ability to make important contributions to immuno-oncology, cancer biology, or related fields, as evidenced by a strong publication, funded grant, and/or patent record.
Demonstrated ability to work independently.
Excellent written and oral communication and presentation skills in English.
Proficiency in all common office and scientific software.
Strong ability to multi-task and work productively in a fast-paced, highly collaborative, and diverse team environment.
Capability to contribute to a vivid and challenging intellectual environment.
Work requires some exertion and dexterity such as standing, sitting, walking, bending, reaching, lifting light objects, and handling small rodents in the vivarium.
Must be willing and able to work after hours as needed to ensure study integrity. Travel may be required to attend meetings and conferences.
Other Job Details
Eligible for Employee Referral Bonus
Relocation Assistance for eligible candidates